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    Peptide Sciences Tirzepatide vs Semaglutide
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    The incretin peptide science tirzepatide family has expanded dramatically over the past decade.
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    Three Peptides, Three Mechanisms
    At a Glance Comparison Table
    Feature Semaglutide Tirzepatide Retatrutide
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    Number of agonists Single Dual (two) Triple (three)
    Half-life (animal models) ~7 days ~5 days ~6 days
    Molecular weight (Da) 4,113.6 4,813.4 ~4,900
    Amino acid length 31 39 ~40
    Peptide Sciences™ purity ≥99% ≥98.5% ≥98%
    Primary research use Selective GLP-1 studies Dual pathway mapping Triple-receptor signaling
    Fatty acid modification C18 at Lys26 C20 at Lys20 C18/C20 hybrid
    DPP-4 resistance Yes (Aib substitutions) Yes (Aib substitutions) Yes (Aib
    substitutions)
    SKU PS-SEMA-5mg PS-TIRZ-10mg PS-RETA-10mg
    The Incretin System: Background for Researchers
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    The two primary incretins are:

    Hormone Receptor Primary Effects Secreted By
    GLP-1 (Glucagon-Like Peptide-1) GLP-1R Insulin secretion, satiety, gastric emptying L-cells (ileum,
    colon)
    GIP (Glucose-dependent Insulinotropic Polypeptide) GIP-R Insulin secretion, fat
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